Publications

PET imaging of cardiac sympathetic nervous system dysfunction using meta-[18F]fluorobenzylguanidine

Ismailani, US; Buchler, A; de Carvalho Tso, J; Pulente, SM; Abdirahman, F; Hoddinott, EL; Fortier, M; Mulvihill, EE;
deKemp, RA; Rotstein, BH.
Eur. J. Nucl. Med. Mol. Imaging 2025, in press
doi: 10.1007/s00259-025-07692-3

Optimization of carbon-11-carboxylate exchange of α-amino acids

Mair, BA; Munch, M; Patel, AP; Buchler, A; Rotstein, BH.
Can. J. Chem. 2025, in press
doi: 10.1139/cjc-2025-0190

Multipurpose on-the-spot peptide-based hydrogels for skin, cornea, and heart repair

Ross, A; Guo, X; Mercado Salazar, GA; Garcia Schejtman, SD; El-Hage, J; Comtois-Bona, M; Macadam, A; Guzman-Soto, I; Takaya, H; Hu, K; Liu, B; Tu, R; Siddiqi, B; Anderson, E; Muñoz, M; Briones-Rebolledo, P; Ning, T; Griffith, M; Rotstein, BH; Poblete, H; Li, J; Ruel, M; Suuronen, EJ; Alarcon, EI.
Adv. Funct. Mater. 2024, 34, 2402564
doi: 10.1002/adfm.202402564

A practical guide for the preparation of C1-labelled α-amino acids using aldehyde catalysis with isotopically labelled CO2

Doyle, MGJ; Mair, BA; Sib, A; Derdau, V; Bsharat, O; Munch, M; Bauer, A; Rotstein, BH; Lundgren, RJ.
Nat. Protoc. 2024, 19, 2147–2179
doi: 10.1038/s41596-024-00974-4

PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway

Hodgins, JJ; Abou-Hamad, J; O’Dwyer, CE; Hagerman, A; Yakubovich, E; Tanese de Souza, C; Marotel, M; Buchler, A; Fadel, S; Park, MM: Fong-McMaster, C; Crupi, MF; Makinson, OJ; Kurdieh, R; Rezaei, R; Dhillon, HS; Ilkow, CS; Bell, JC; Harper, M-E; Rotstein, BH; Auer, RC; Vanderhyden, BC; Sabourin, LA; Bourgeois-Daignault, M-C; Cook, DP; Ardolino, M.
J. Exp. Med. 2024, 221, e20221721
doi: 10.1084/jem.20221721

Intramolecular Friedel-Crafts acylation of carbon-11 isocyanates enabling the radiolabeling of [carbonyl-11C]DPQ

Ozenil, M; Kolger, L; Mair, BA; Hacker, M; Wadsak, W; Rotstein BH; Pichler, V.
Chem. Eur. J.2024, 30, e202400581
doi: 10.1002/chem.202400581

Photocatalyzed radiosynthesis of 11C-phenylacetic acids

Munch, M; Mair, BA; Adi, M; Rotstein, BH
J. Label. Compd. Radiopharm. 2024, 67, 211–216
doi: 10.1002/jlcr.4073

Pharmacological and metabolic parameters of [18F]flubrobenguane in clinical imaging populations

Mair, BA; Zelt, JGE; Nekesa, K; Saint-Georges, Z; Dinelle, K; Adi, M; Robinson, S; Mielniczuk, LM; Shlik, J; Beanlands, RS; deKemp, RA; Rotstein, BH
J. Nucl. Cardiol. 2023, 30, 2089–2095.
doi: 10.1007/s12350-023-03338-9

Quinazoline-2-carboxamides as selective PET radiotracers for matrix metalloproteinase-13 imaging in atherosclerosis

Buchler, A; Ismailani, US; MacMullin, N; Abdirahman, F; Adi, M; Bi, C; Jany, C; Keillor, JW; Rotstein, BH
J. Med. Chem. 2023, 66, 6682–6696.
doi: 10.1021/acs.jmedchem.2c02107

Synthesis and evaluation of [11C]MCC950 for imaging NLRP3-mediated inflammation in atherosclerosis

Ismailani, US; Buchler, A; MacMullin, N; Abdirahman, F; Adi, M; Rotstein, BH
Mol. Pharmaceutics 2023, 20, 1709–1716.
doi: 10.1021/acs.molpharmaceut.2c00915

Aldehyde-catalysed carboxylate exchange in α-amino acids with isotopically labelled CO2

Bsharat, O; Doyle, MGJ; Munch, M; Mair, BA; Cooze, CJC; Derdau, V; Bauer, A; Kong, D; Rotstein, BH; Lundgren, RJ
Nat. Chem. 2022, 14, 1367‒1374.
doi: 10.1038/s41557-022-01074-0

Nanoengineered sprayable therapy for treating myocardial infarction

Muñoz, M; Cimenci, CE; Goel, K; Comtois-Bona, M; Hossain, M; McTiernan, C; Zuñiga-Bustos, M; Ross, A; Truong, B;
Davis, DR; Liang, W; Rotstein, BH; Ruel, M; Poblete, H; Suuronen, EJ; Alarcon, EI
ACS Nano 2022, 16, 3522–3537.
doi: 10.1021/acsnano.1c08890

Does quantification of [11C]meta-hydroxyephedrine and [13N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy?

Wang, JZ; Zelt, JGE; Kaps, N; Lavallee, A; Renaud, JM; Rotstein, BH; Beanlands, RSB; Fallavollita, JA; Canty Jr, JM; deKemp, RA
J. Nucl. Cardiol. 2022, 29, 413–425.
doi: 10.1007/s12350-021-02732-5

The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication

Davarinejad, H; Huang, Y-C; Mermaz, B; LeBlanc, C; Poulet, A; Thomson, G; Joly, V; Muñoz, M; Arvanitis-Vigneault, A; Valsakumar, D; Villarino, G; Ross, A; Rotstein, BH; Alarcon, EI; Brunzelle, JS; Dong, J; Couture, J-F; Jacob, Y
Science 2022, 375, 1281–1286.
doi: 10.1126/science.abm5320

Selective imaging of matrix metalloproteinase-13 to detect extracellular matrix remodeling in atherosclerotic lesions

Buchler, A; Munch, M; Farber, G; Zhao, X; Al-Haddad, R; Farber, E; Rotstein, BH
Mol. Imaging Biol. 2022, 24, 93‒103.
doi: 10.1007/s11307-021-01626-9

Combined methylglyoxal scavenger and collagen hydrogel therapy prevents adverse remodeling and improves cardiac function post-myocardial infarction

Cimenci, CE; Blackburn, NJR; Sedlakova, V; Pupkaite, J; Munoz, M; Rotstein, BH; Spiegel, DA; Alarcon, EI; Suuronen, EJ
Adv. Funct. Mater. 2022, 32, 2108630.
doi: 10.1002/adfm.202108630

Cardiac sympathetic PET imaging with meta-[18F]fluorobenzylguanidine is sensitive to uptake‑1 in rats

Ismailani, US; Buchler, A; Farber, G; Pekošak, A; Farber, E; MacMullin, N; Suuronen, EJ; Vasdev, N; Beanlands, RSB; deKemp, RA; Rotstein, BH
ACS Chem. Neurosci. 2021, 12, 4350–4360.
doi: 10.1021/acschemneuro.1c00575

Evaluation of therapeutic collagen-based biomaterials in the infarcted mouse heart by extracellular matrix targeted MALDI imaging mass spectrometry

Clift, CL; McLaughlin, S; Muñoz, M; Suuronen, EJ; Rotstein, BH; Mehta, A; Drake, RR; Alarcon, EI; Angel, PM
J. Am. Soc. Mass Spectrom. 2021, 32, 2746–2754.
doi: 10.1021/jasms.1c00189

Riboflavin surface modification of poly(vinyl chloride) for light-triggered control of bacterial biofilm and virus inactivation

Munoz, M; El-khoury, A; Cimenci, CE; Gonzalez-Gomez, M; Hunter, RA; Lonboni, D; Variola, F; Rotstein, BH; Vono, LLR; Rossi, LM; Edwards, AM; Alarcon, EI
ACS Appl. Mater. Interfaces 2021, 13, 32251–32262.
doi: 10.1021/acsami.1c08042

Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11C-carbonyls

Ismailani, US; Munch, M; Mair, BA; Rotstein, BH
Chem. Commun. 2021, 57, 5266–5269.
doi: 10.1039/d1cc01016f

A low cost & open access system for rapid synthesis of large volumes of gold and silver nanoparticles

Ross, A; Muñoz, M; Rotstein, BH; Suuronen, E; Alarcon, EI
Sci. Rep. 2021, 11, 5420.
doi: 10.1038/s41598-021-84896-1

Fast carbon isotope exchange of carboxylic acids enabled by organic photoredox catalysis

Kong, D; Munch, M; Qiqige, Q; Cooze, CJC; Rotstein, BH; Lundgren, RJ
J. Am. Chem. Soc. 2021, 143, 2200-2206.
doi: 10.1021/jacs.0c12819

Regional distribution of fluorine-18-flubrobenguane and carbon-11-hydroxyephedrine for cardiac PET imaging of sympathetic innervation

Zelt, JGE; Britt, D; Mair, BA; Rotstein BH; Quigley, S; Walter, O; Garrard, L; Robinson, S; Mielniczuk, LM; deKemp, RA; Beanlands, RS
JACC Cardiovasc. Imaging 2021, 14, 1425-1436.
doi: 10.1016/j.jcmg.2020.09.026

Fluorine-18 labeled fluorescent dyes for dual-mode molecular imaging

Munch, M; Rotstein, BH; Ulrich, G
Molecules 2020, 25, 6042.
doi: 10.3390/molecules25246042

Innate immune Nod1/RIP2 signaling is essential for cardiac hypertrophy, but requires mitochondrial antiviral signaling protein (MAVS) for signal transduction and energy balance

Lin, HB; Naito, K; Oh, Y; Farber, G; Kanaan, G; Valaperti, A; Dawood, F; Zhang, L; Li, GH; Smyth; D; Moon, M; Liu, Y;
Liang, W; Rotstein, BH; Philpott, D; Kim, KH; Harper, ME; Liu, P
Circulation 2020, 142, 2240-2258.
doi: 10.1161/circulationaha.119.041213

First-in-human imaging and kinetic analysis of vesicular acetylcholine transporter density in the heart using [18F]FEOBV PET

Saint-Georges, Z; Zayed, VK; Dinelle, K; Cassidy, C; Soucy JP; Massarweh, G; Rotstein, BH; Nery, PB; Guimond, S;
deKemp, RA; Tuominen, L
J. Nucl. Cardiol. 2021, 28, 50-54.
doi: 10.1007/s12350-020-02323-w

The Future of Cardiac Molecular Imaging

Farber, G; Boczar, KE; Wiefels, CC; Zelt, JGE; Guler, EC; deKemp, RA; Beanlands, RS; Rotstein, BH
Semin. Nucl. Med. 2020, 50, 367-385.
doi: 10.1053/j.semnuclmed.2020.02.005

Rhodium-catalyzed addition of organozinc iodides to carbon‑11 isocyanates

Mair, BA; Fouad, MH; Ismailani, US; Munch, M; Rotstein, BH
Org. Lett. 2020, 22, 2746–2750
doi: 10.1021/acs.orglett.0c00729

PET and SPECT tracers for myocardial perfusion imaging

Klein, R; Guler, EC; Rotstein, BH, deKemp, RA
Semin. Nucl. Med. 2020, 50, 208–‍218
doi: 10.1053/j.semnuclmed.2020.02.016

Nuclear imaging of the cardiac sympathetic nervous system: A disease specific interpretation in heart failure

Zelt, JGE; deKemp, RA; Rotstein, BH; Nair, GM; Narula, J; Ahmadi, A; Beanlands, RS; Mielniczuk, LM
JACC Cardiovasc. Imaging 2020, 13, 1036–1054
doi: 10.1016/j.jcmg.2019.01.042

Current and future cardiovascular PET radiopharmaceuticals

Al-Haddad, R; Ismailani, US; Rotstein, BH
PET Clinics. 2019, 14, 293–305
doi: 10.1016/j.cpet.2018.12.010

Facile 18F-labeling of non-activated arenes via a spirocyclic iodonium(III) ylide method and its application in the synthesis of the mGluR5 PET radiopharmaceutical [18F]FPEB

Liang, SH; Wang, L; Stephenson, NA; Rotstein, BH; Vasdev, N
Nat. Protoc. 2019, 14, 1530–1545
doi: 10.1038/s41596-019-0149-3

Stereoselective ¹¹C-Labeling of a "Native" Tetrapeptide Using Asymmetric Phase-Transfer Catalyzed Alkylation Reactions

Pekošak, A; Rotstein, BH; Collier, TL; Windhorst, AD; Vasdev, N; Poot, AJ
Eur. J. Org. Chem. 2017, 1019–1024
doi: 10.1002/ejoc.201601641

Metal-free 18F Labeling of aryl CF2H via nucleophilic radiofluorination and oxidative C-H activation

Yuan, G; Wang, F; Stephenson, NA; Wang, L; Rotstein, BH; Vasdev, N; Tang, P; Liang, SH
Chem. Commun. 2017, 53, 126–129
doi: 10.1039/c6cc07913j

Development of [18F]maleimide-based glycogen synthase kinase-3β ligands for positron emission tomography imaging

Hu, K; Patnaik, D; Collier, TL; Lee, KN; Gao, H; Swoyer, M; Rotstein, BH; Krishnan, HS; Liang, SH; Wang, J; Yan, Z; Hooker, JM; Vasdev, N; Haggarty, SJ; Ngai, M-Y
ACS Med. Chem. Lett. 2017, 8, 287–292
doi: 10.1021/acsmedchemlett.6b00405

Preclinical PET neuroimaging of [11C]bexarotene

Rotstein, BH; Placzek, MS; Krishnan, HS; Pekošak, A; Collier, TL; Wang, C; Liang, SH; Burstein, ES; Hooker, JM; Vasdev, N
Mol. Imaging 2016, 15, 1–5
doi: 10.1177/1536012116663054

11C═O bonds made easily for positron emission tomography

Rotstein, BH; Liang, SH; Placzek, MS; Hooker, JM; Gee, AD; Dollé, F; Wilson, AA; Vasdev, N
Chem. Soc. Rev. 2016, 45, 4708–4726
doi: 10.1039/c6cs00310a

Synthesis and preclinical evaluation of sulfonamido-based [11C-carbonyl]-carbamates and ureas for imaging monoacylglycerol lipase

Wang, L; Mori, W; Cheng, R; Yui, J; Hatori, A; Ma, L; Zhang, Y; Rotstein, BH; Fujinaga, M; Shimoda, Y; Yamasaki, T; Xie, L; Nagai, Y; Minamimoto, T; Higuchi, M; Vasdev, N; Zhang, M-R; Liang, SH
Theranostics 2016, 6, 1145–1159
doi: 10.7150/thno.15257

Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(III) ylides

Rotstein, BH; Wang, L; Liu, RY; Patteson, J; Kwan, EE: Vasdev, N; Liang, SH
Chem. Sci. 2016, 7, 4407–4417
doi: 10.1039/c6sc00197a

Synthesis and preliminary PET imaging studies of a FAAH radiotracer ([11C]MPPO) based on α-ketoheterocyclic scaffold

Wang, L; Yui, J; Wang, Q; Zhang, Y; Mori, W; Shimoda, Y; Fujinaga, M; Kumata, K; Yamasaki, T; Hatori, A; Rotstein, BH; Collier, TL; Ran, C; Vasdev, N; Zhang, M-R; Liang, SH
ACS Chem. Neurosci. 2016, 7, 109–118
doi: 10.1021/acschemneuro.5b00248

Ortho-stabilized 18F-azide click agents and application in PET imaging of single-stranded DNA aptamer

Wang, L; Jacobsen, O; Advic, D; Rotstein, BH; Weiss ID; Collier TL; Chen X; Vasdev, N; Liang, SH
Angew. Chem. Int. Ed. 2015, 54, 12777–‍12781
doi: 10.1002/anie.201505927

Practical radiosynthesis and preclinical neuroimaging of [11C]isradipine, a calcium channel antagonist

Rotstein, BH; Liang, SH; Belov, VV; Livni, E; Levine, DB; Bonab, AA; Papisov, MI; Perlis, RH; Vasdev, N
Molecules 2015, 20, 9551–9559
doi: 10.3390/molecules20069550

PET neuroimaging studies of [18F]CABS13 in a double transgenic mouse model of Alzheimer’s disease and nonhuman primates

Liang, SH; Holland, JP; Stephenson, NA; Kassenbrock, A; Rotstein, BH; Daignault, C; Lewis, R; Collier, TL; Hooker, JM; Vasdev, N
ACS Chem. Neurosci. 2015, 6, 535–541
doi: 10.1021/acschemneuro.5b00055

Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics

Rotstein, BH; Stephenson, NA; Vasdev, N; Liang, SH
Nat. Commun. 2014, 5, 4365
doi: 10.1038/ncomms5365

PET imaging of fatty acid amide hydrolase with [18F]DOPP in non-human primates

Rotstein, BH; Wey, H-Y; Shoup, TM; Wilson, AA; Liang, SH; Hooker, JM; Vasdev, N
Mol. Pharmaceutics 2014, 11, 3832–3838
doi: 10.1021/mp500316h

Synthesis of [11C]bexarotene by Cu‑mediated [11C]carbon dioxide fixation and preliminary PET imaging

Rotstein, BH; Hooker, JM; Woo, J; Collier, TL; Brady, TJ; Liang, SH; Vasdev, N
ACS Med. Chem. Lett. 2014, 5, 668–672
doi: 10.1021/ml500065q

Small heterocycles in multicomponent reactions

Rotstein, BH; Zaretsky, S; Rai, V; Yudin, AK
Chem. Rev. 2014, 114, 8323–8359
doi: 10.1021/cr400615v

Stereocontrolled disruption of the Ugi reaction toward the production of chiral piperazinones: Substrate scope and process development

Zaretsky, S.; Adachi, S.; Rotstein, BH; Hickey, JL; Scully, CCG; St. Denis, JD; Courtemanche, R; Yu, J; Chung, BKW; Yudin AK
J. Org. Chem. 2014, 79, 9948–9957
doi: 10.1021/jo5018316

Shifting the energy landscape of multicomponent reactions using aziridine aldehyde dimers: A mechanistic study

Belding, L; Zaretsky, S; Rotstein, BH; Yudin, AK.; Dudding, T
J. Org. Chem. 2014, 79, 9465–9471
doi: 10.1021/jo501242r

Alternative approaches for PET radiotracer development in Alzheimer’s disease: Imaging beyond plaque

Holland, JP; Liang, SH; Rotstein, BH; Collier, TL; Stephenson, NA; Greguric, I; Vasdev, N
J. Labelled Compd. Radiopharm. 2014, 57, 323–‍331
doi: 10.1002/jlcr.3158

Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

Liang, SH; Collier, TL; Rotstein, BH; Lewis, R; Steck, M; Vasdev, N
Chem. Commun. 2013, 49, 8755–8757
doi: 10.1039/c3cc45166f

11CO2 fixation: A renaissance in PET radiochemistry

Rotstein, BH; Liang, SH; Holland, JP; Collier, TL; Hooker, JM; Wilson, AA; Vasdev, N
Chem. Commun. 2013, 49, 5621–5629
doi: 10.1039/c3cc42236d

Aziridine-2-carboxaldehyde dimers undergo homo-Ugi 4-component-5-centre reactions

Rotstein, BH; Yudin, AK
Synthesis 2012, 44, 2851–2858
doi: 10.1055/s-0030-1260261

Conformational modulation of in vitro activity of cyclic RGD peptides via aziridine aldehyde-driven macrocyclization chemistry

Roxin, Á; Chen, J; Scully, CCG; Rotstein, BH; Yudin, AK; Zheng, G
Bioconjugate Chem. 2012, 23, 1387–1395
doi: 10.1021/bc300239a

Thioester-isocyanides: Versatile reagents for the synthesis of cycle-tail peptides

Rotstein, BH; Winternheimer, DJ; Yin, LM; Deber, CM; Yudin, AK
Chem. Commun. 2012, 48, 3775–3777
doi: 10.1039/c2cc16027g

Solvatochromic reagents for multicomponent reactions and their utility in the development of cell-permeable macrocyclic peptide vectors

Rotstein, BH; Mourtada, R; Kelley, SO; Yudin, AK
Chem. Eur. J. 2011, 17, 12257–12261
doi: 10.1002/chem.201102096

Synthesis of peptide macrocycles using unprotected amino aldehydes

Rotstein, BH; Rai, V; Hili, R; Yudin, AK
Nat. Protoc. 2010, 5, 1813–1822
doi: 10.1038/nprot.2010.127

Comparison of benzene, nitrobenzene, and dinitrobenzene 2-arylsulfenylpyrroles

Garabatos-Perera, JR; Rotstein, BH; Thompson, A
J. Org. Chem. 2007, 72, 7382–7385
doi: 10.1021/jo070493r