Publications

23. Rotstein, BH; Placzek, MS; Krishnan, HS; Pekošak, A; Collier, TL; Wang, C; Liang, SH; Burstein, ES; Hooker, JM; Vasdev, N. “Preclinical PET neuroimaging of [11C]bexarotene.Mol. Imaging 2016, in press.

22. Rotstein, BH; Liang, SH; Placzek, MS; Hooker, JM; Gee, AD; Dollé, F; Wilson, AA; Vasdev, N. “11C═O bonds made easily for positron emission tomography.Chem. Soc. Rev. 2016, 45, 4708–4726.

 

21. Wang, L; Mori, W; Cheng, R; Yui, J; Hatori, A; Ma, L; Zhang, Y; Rotstein, BH; Fujinaga, M; Shimoda, Y; Yamasaki, T; Xie, L; Nagai, Y; Minamimoto, T; Higuchi, M; Vasdev, N; Zhang, M-R; Liang, SH. “Synthesis and preclinical evaluation of sulfonamido-based [11C-carbonyl]-carbamates and ureas for imaging monoacylglycerol lipase.Theranostics 20166, 1145–1159.

20. Rotstein, BH; Wang, L; Liu, RY; Patteson, J; Kwan, EE: Vasdev, N; Liang, SH. “Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(III) ylides.Chem. Sci. 2016, 7, 4407–4417.

19. Wang, L; Yui, J; Wang, Q; Zhang, Y; Mori, W; Shimoda, Y; Fujinaga, M; Kumata, K; Yamasaki, T; Hatori, A; Rotstein, BH; Collier, TL; Ran, C; Vasdev, N; Zhang, M-R; Liang, SH. “Synthesis and preliminary PET imaging studies of a FAAH radiotracer ([11C]MPPO) based on α-ketoheterocyclic scaffold.ACS Chem. Neurosci. 20167, 109–118.

18. Wang, L; Jacobsen, O; Advic, D; Rotstein, BH; Weiss ID; Collier TL; Chen X; Vasdev, N; Liang, SH. “Ortho-stabilized 18F-azide click agents and application in PET imaging of single-stranded DNA aptamer.
Angew. Chem. Int. Ed. 201554, 12777–12781.

17. Rotstein, BH; Liang, SH; Belov, VV; Livni, E; Levine, DB; Bonab, AA; Papisov, MI; Perlis, RH; Vasdev, N. “Practical radiosynthesis and preclinical neuroimaging of [11C]isradipine, a calcium channel antagonist.Molecules 201520, 9551–9559.

16. Liang, SH; Holland, JP; Stephenson, NA; Kassenbrock, A; Rotstein, BH; Daignault, C; Lewis, R; Collier, TL; Hooker, JM; Vasdev, N. “PET neuroimaging studies of [18F]CABS13 in a double transgenic mouse model of Alzheimer’s disease and nonhuman primates.ACS Chem. Neurosci. 2015, 6, 535–541.

 

15. Rotstein, BH; Stephenson, NA; Vasdev, N; Liang, SL. “Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics.Nat. Commun. 2014, 5, 4365.

14. Rotstein, BH; Wey, H-Y; Shoup, TM; Wilson, AA; Liang, SH; Hooker, JM; Vasdev, N. “PET imaging of fatty acid amide hydrolase with [18F]DOPP in non-human primates.Mol. Pharmaceutics 2014, 11, 3832–3838.

 

13. Rotstein, BH; Hooker, JM; Woo, J; Collier, TL; Brady, TJ; Liang, SH; Vasdev, N. “Synthesis of [11C]bexarotene by Cu‑mediated [11C]carbon dioxide fixation and preliminary PET imaging.ACS Med. Chem. Lett. 2014, 5, 668–672.

12. Rotstein, BH; Zaretsky, S; Rai, V; Yudin, AK. “Small ring heterocycles in multicomponent reactions.Chem. Rev. 2014114, 8323–8359.

11. Zaretsky, S.; Adachi, S.; Rotstein, BH; Hickey, JL; Scully, CCG; St. Denis, JD; Courtemanche, R; Yu, J; Chung, BKW; Yudin AK. “Stereocontrolled disruption of the Ugi reaction toward the production of chiral piperazinones: Substrate scope and process development.J. Org. Chem. 2014, 79, 9948–9957.

10. Belding, L; Zaretsky, S; Rotstein, BH; Yudin, AK.; Dudding, T. “Shifting the energy landscape of multicomponent reactions using aziridine aldehyde dimers: A mechanistic study.J. Org. Chem. 2014, 79, 9465–9471.

09. Holland, JP; Liang, SH; Rotstein, BH; Collier, TL; Stephenson, NA; Greguric, I; Vasdev, N. “Alternative approaches for PET radiotracer development in Alzheimer’s disease: Imaging beyond plaque.J. Labelled Compd. Radiopharm. 201457, 323–331.

08. Liang, SH; Collier, TL; Rotstein, BH; Lewis, R; Steck, M; Vasdev, N. “Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds.Chem. Commun. 2013, 49, 8755–8757.

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07. Rotstein, BH; Liang, SH; Holland, JP; Collier, TL; Hooker, JM; Wilson, AA; Vasdev, N. “11CO2 fixation: A renaissance in PET radiochemistry.Chem. Commun. 2013, 49, 5621–5629.

06. Rotstein, BH; Yudin, AK. “Aziridine-2-carboxaldehyde dimers undergo homo-Ugi 4-component-5-centre reactions.Synthesis 2012, 44, 2851–2858.

05. Roxin, Á; Chen, J; Scully, CCG; Rotstein, BH; Yudin, AK; Zheng, G. “Conformational modulation of in vitro activity of cyclic RGD peptides via aziridine aldehyde-driven macrocyclization chemistry.Bioconjugate Chem. 201223, 1387–1395.

04. Rotstein, BH; Winternheimer, DJ; Yin, LM; Deber, CM; Yudin, AK. “Thioester-isocyanides: Versatile reagents for the synthesis of cycle-tail peptides.Chem. Commun. 2012, 48, 3775–3777.

03. Rotstein, BH; Mourtada, R; Kelley, SO; Yudin, AK. “Solvatochromic reagents for multicomponent reactions and their utility in the development of cell-permeable macrocyclic peptide vectors.Chem. Eur. J. 2011, 17, 12257–12261.

02. Rotstein, BH; Rai, V; Hili, R; Yudin, AK. “Synthesis of peptide macrocycles using unprotected amino aldehydes.Nat. Protoc. 2010, 5, 1813–1822.

01. Garabatos-Perera, JR; Rotstein, BH; Thompson, A. “Comparison of benzene, nitrobenzene, and dinitrobenzene 2-arylsulfenylpyrroles.J. Org. Chem. 2007, 72, 7382–7385.